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Article: Research reports on cell biology from Washington University, Medical Department provide new insights.
- Article from:
- Science Letter
- Article date:
- October 13, 2009
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"The nuclear receptor PPAR alpha is activated by drugs to treat human disorders of lipid metabolism. Its endogenous ligand is unknown," scientists in the United States report (see also Cell Biology).
"PPAR alpha-dependent gene expression is impaired with inactivation of fatty acid synthase (FAS), suggesting that FAS is involved in generation of a PPAR alpha ligand. Here we demonstrate the FAS-dependent presence of a phospholipid bound to PPAR alpha isolated from mouse liver. Binding was increased under conditions that induce FAS activity and displaced by systemic injection of a PPAR alpha agonist. Mass spectrometry identified the species as ...