Article: Research from Bharathiar University yields new data on theoretical & computational chemistry.

According to recent research from Coimbatore, India, "A density functional study on the interaction of Cu2+ and Zn2+ metal ions at the predominant positions of N-tau-H and N-pi-H histidine tautomers has been performed. The fully optimized energy of the isolated histidine tautomers at B3LYP/6-311++G* level of theory depicts N-tau-H tautomer to be much stable compared to that of the N-pi- H tautomer."

"The interaction of metal ions forms bidentate and tridentate complexes with N-tau-H tautomer, while it is absent in the case of N-pi-H tautomer emphasizing the role of former in structural determination of liganated proteins. The Zn2+ ion induces a barrier-free ...

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