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Article: Studies from Z. Novakova and colleagues reveal new findings on enzyme research.
- Article from:
- Biotech Week
- Article date:
- October 21, 2009
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"A spontaneous mutant of Methanothermobacter thermautotrophicus resistant to tributyltin chloride (TBT) was isolated. TBT, the inhibitor of the A(0) domain of A(1)A(0)-ATP synthase, inhibits methanogenesis in the wild-type cells; however, the TBT-resistant mutant exhibited methanogenesis even in the presence of 800 mc M TBT," researchers in Slovakia report (see also Enzyme Research).
"ATP synthesis driven by methanogenic electron transport was markedly diminished in the mutant strain. While TBT profoundly inhibited ATP synthesis driven by methanogenic electron transport in the wild type, only a slight inhibition was observed in the mutant strain. These results ...