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Article: Reports from V.J.N. Bykov and colleagues advance knowledge in apoptosis.
- Article from:
- Cancer Weekly
- Article date:
- October 20, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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According to a study from Stockholm, Sweden, "The p53 tumor suppressor is a key regulator of cell growth and survival upon various forms of cellular stress. p53 is a redox-regulated transcription factor that binds specifically to DNA and activates transcription of target genes. The core domain of p53 holds a zinc atom that protects p53 from oxidation and is critical for DNA binding."
"A large fraction of human tumors carry p53 mutation, allowing evasion of apoptosis and tumor progression. Restoration of wild type p53 expression triggers rapid elimination of tumors in vivo. This makes mutant p53 an attractive target for novel cancer therapy. Small molecules have ...