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Article: Research from Rockefeller University has provided new information about enzyme research.
- Article from:
- Cancer Weekly
- Article date:
- October 20, 2009
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"We present evidence, using biochemical and cellular approaches, that the kinase, CK2, negatively controls signaling via G alpha(s) (or G alpha(olf)) coupled to dopamine D1 and adenosine A2A receptors. Pharmacological inhibition of CK2 or CK2 knockdown by RNAi lead to elevated cAMP levels in dopamine D1 receptor-activated neuroblastoma cells," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report (see also Enzyme Research).
"Phosphorylation levels of protein kinase A substrates were increased in the presence of CK2 inhibitors in mouse striatal slices. The effect of D1 receptor and A2A receptor ...