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Article: Type I keratin 16 forms relatively unstable tetrameric assembly subunits with various type II keratin partners: biochemical basis and functional implications. (includes panel discussion)(The Cytoskeleton: Mechanical, Physical, and Biological Interactions)
- Article from:
- The Biological Bulletin
- Article date:
- June 1, 1998
- Author:
CopyrightCOPYRIGHT 1998 Marine Biological Laboratory. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Type II keratin 6 (K6) and type I keratins 16 and 17 (K16 and K17) are intermediate-filament (IF) proteins that are induced in wound-edge keratinocytes as early as 4-6 h after injury to skin, either human or mouse. This induction occurs at the expense of the keratin proteins that are normally expressed in differentiating epidermal keratinocytes. Correlated with these changes in protein expression, keratinocytes - for 24 h following injury - undergo major cytoarchitectural alterations that affect their shape, intracellular organization, surface morphology, and adhesion properties. We recently proposed that the intrinsic properties of K16 are compatible with a direct role in ...