Article: Data from University of Rochester provide new insights into arthritis.(Report)

According to recent research from the United States, "This study was undertaken to investigate the effect of lymphatic inhibition on joint and draining lymph node (LN) pathology during the course of arthritis progression in mice. Tumor necrosis factor (TNF)-transgenic mice were used as a model of chronic inflammatory arthritis."

"Mice were subjected to contrast-enhanced magnetic resonance imaging to obtain ankle and knee joint synovial volumes and draining popliteal LN volumes before and after 8 weeks of treatment with vascular endothelial growth factor receptor 3 (VEGFR-3) neutralizing antibody, VEGFR-2 neutralizing antibody, or isotype IgG. Animals were ...

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