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Article: Studies conducted at Mental Health Research Institute on schizophrenia therapy recently published.(Report)
- Article from:
- Biotech Week
- Article date:
- November 4, 2009
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A report, 'Neuregulin 1 hypomorphic mutant mice: enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation,' is newly published data in The International Journal of Neuropsychopharmacology. "Neuregulin 1 (Nrg1) has been widely recognized as a candidate gene for schizophrenia. This study therefore investigated mice heterozygous for a mutation in the transmembrane domain of this trophic factor (Nrg1[+ or -]mice) in a number of behavioural test systems with relevance to schizophrenia, including psychotropic drug-induced locomotor hyperactivity and prepulse inhibition (PPI) of startle," scientists writing in ...