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Article: Research results from E. Hodges and co-authors update knowledge of DNA research.
- Article from:
- Cancer Weekly
- Article date:
- November 3, 2009
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"DNA methylation stabilizes developmentally programmed gene expression states. Aberrant methylation is associated with disease progression and is a common feature of cancer genomes," researchers in the United States report (see also DNA Research).
"Presently, few methods enable quantitative, large-scale, single-base resolution mapping of DNA methylation states in desired regions of a complex mammalian genome. Here, we present an approach that combines array-based hybrid selection and massively parallel bisulfite sequencing to profile DNA methylation in genomic regions spanning hundreds of thousands of bases. This single molecule strategy enables methylation ...