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Article: Researchers from University of Colorado report recent findings in trivalent vaccines.
- Article from:
- Vaccine Weekly
- Article date:
- November 4, 2009
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"The adsorption of recombinant botulinum neurotoxin (BoNT) protein-derived vaccine antigens to aluminum salt adjuvants has been previously studied for the development of a trivalent vaccine against the neurotoxins (Vessely et al., in press, J Pharm Sci). The current paper describes an investigation of the stability of recombinant BoNT antigens adsorbed to aluminum salt adjuvants during storage in aqueous solution," scientists writing in the Journal of Pharmaceutical Sciences report (see also Trivalent Vaccines).
"Both chemical and physical changes occurred during storage. Phosphate groups in the buffer exchanged with hydroxyl groups on the adjuvant surface. The ...