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Article: Research from New York University in the area of enzyme research described.
- Article from:
- Proteomics Weekly
- Article date:
- November 2, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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According to recent research published in the journal Molecular Biology of the Cell, "The Ca2+-activated K+ channel KCa3.1 is required for Ca2+ influx and the subsequent activation of T-cells. We previously showed that nucleoside diphosphate kinase beta (NDPK-B), a mammalian histidine kinase, directly phosphorylates and activates KCa3.1 and is required for the activation of human CD4 T lymphocytes."
"We now show that the class II phosphatidylinositol 3 kinase C2 beta (PI3K-C2 beta) is activated by the T-cell receptor (TCR) and functions upstream of NDPK-B to activate KCa3.1 channel activity. Decreased expression of PI3K-C2 beta by siRNA in human CD4 T-cells ...
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Article: Findings from New York University provide ...
Health & Medicine Week;
February 18, 2008 ;
700+ words
... ... Gennaro and colleagues, New York University. The researchers concluded ... information, contact S. Gennaro, New York University, College Nursing, 246 Greene ... Life Sciences, Nursing, New York University. This article was prepared ...
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