Article: Epigenetics Gains Momentum; Novartis Teams up with Orion.

Staff Writer

Orion Genomics LLC is expected to announce on Monday a collaboration with Novartis AG aimed at discovering epigenetic biomarkers for use in diagnostics.

Terms for the deal were not disclosed, although St. Louis-based Orion and Basel, Switzerland-based Novartis each will retain rights to commercialize certain resulting diagnostics.

Epigenetics refers to how gene expression is influenced by structural modifications, such as DNA methylation or histone acetylation, that change the way a DNA sequence is packaged without changing the sequence itself. The classic example is stem cells, which divide and differentiate to become every cell ...

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