Article: NewCo News: CalciMedica Gains Access To Programs In Calcium Channels.

Staff Writer

CalciMedica Inc. is carving out a niche in the autoimmune and inflammatory field by focusing on calcium release-activated calcium (CRAC) channels, which are critical to the release of interleukin-2, TNF-alpha and other cytokines involved in the immune response.

Back in 2005, scientists at TorreyPines Therapeutics Inc. pinpointed the STIM1 gene as a key connection between the release of stored calcium and the activation of CRAC channels. Not long afterward, scientists at Harvard Medical School's CBR Institute for Biomedical Research Inc. (CBRI) discovered a CRAC channel called Orai1, which is believed to work with STIM1 as a gatekeeper of the ...

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