Article: FoldRx Kicks Off Phase II/III Against Genetic Neuropathy.

West Coast Editor

FoldRx Pharmaceuticals Inc. started the Phase II/III study with Fx-1006A for the first niche disease targeted - familial amyloid polyneuropathy, a fatal genetic disorder that afflicts about 10,000 people worldwide.

Richard Labaudiniere, president and CEO of Cambridge, Mass.-based FoldRx, said the firm expects to have data from the trial by 2009, and to file for approval shortly thereafter.

"This will be one of the first examples of an oral drug to correct protein misfolding and stop disease progression," he said, noting that the company has a separate, yeast-based platform developed from work done by Susan Lindquist, professor ...

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