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o Acceleron Pharma Inc., of Cambridge, Mass., said preclinical results demonstrated that ACE-011, its anabolic bone agent to treat bone loss, preserved bone mass and architecture in a murine model of multiple myeloma. In the study, mice treated with ACE-011 maintained their bone mass, while untreated mice developed substantial bone loss as a result of the myeloma. Histomorphometry analysis revealed that mice given ACE-011 had normal bone formation parameters, while untreated mice had reduced bone formation and increased bone resorption. Data were presented at the International Myeloma Workshop in Kos, Greece.

o Amgen Inc., of Thousand Oaks, Calif., submitted ...

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