Article: Metabolex's Multi-Part Deal With Ortho: $548M Potential.

West Coast Editor

Just after kicking off a Phase II/III trial with its lead insulin sensitizer, metaglidasen, in Type II diabetes, Metabolex Inc. entered a development and commercialization deal with Ortho-McNeil Inc. for that indication, as well as obesity and dyslipidemia, worth up to $548 million plus royalties.

The agreement includes metaglidasen and MBX-2044, as well as follow-on compounds for which Ortho, a subsidiary of Madison, N.J.-based Johnson & Johnson, gets an exclusive license.

"We have agreed upon plans, all the way to registration, for both of those compounds," said Harold Van Wart, president and CEO of Hayward, Calif.-based ...

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