Article: Mouse Model May Help Better Quantify Gene Therapy Risks.

Article: When Gene Therapy Makes Cells Hit The SCIDs.
BIOWORLD Today;  August 11, 2006 ;     700+ words ... ... they were treated with gene therapy to reconstitute the gamma chain, they showed a high ... leukemia to occur after gamma chain gene therapy, mice needed to lack ... causing effects of gamma chain gene therapy. Sorrentino said that ...

Article: After Study, Doctors Unclear On Clinical Risks For Gene ...
BIOWORLD Today;  November 3, 2009 ;     700+ words ... ... lymphomas six months after gene therapy, while the first mice treated ... But IL2RG codes for the gamma chain of the interleukin-2 receptor ... somehow altered when the gamma chain is delivered via gene therapy. In clinical circles, the ...

Article: Gene Therapy Restored Thymic Function In Child With ...
Gene Therapy Weekly;  April 5, 2001 ;     490 words ... ... development followed gene therapy. Previous reports have ... male after he underwent gene therapy for X-linked severe ... linked SCID. A common gamma chain was identified and the child received gene therapy to correct this defect ...

Article: Gene Therapy Restored Thymic Function In Child With ...
Immunotherapy Weekly;  April 4, 2001 ;     609 words ... ... development followed gene therapy. Previous reports have ... male after he underwent gene therapy for X-linked severe ... linked SCID. A common gamma chain was identified and the child received gene therapy to correct this defect ...

Article: Israeli Inventors Develop Receptor Gamma Chain ...
US Fed News Service, Including US State News;  September 4, 2008 ;     419 words ... ... Israel, have developed an interleukin-2 (IL-2) receptor gamma chain production system. According to the U.S. Patent & ... invention relates to the use of the interleukin-2 common gamma chain and related molecules for the modulation of signal activities ...

Article: Human IL-21 and IL-4 bind to partially overlapping epitopes of ...
Immunotherapy Weekly;  March 19, 2003 ;     631 words ... ... consisting of the IL-21 receptor (IL-21R) and the common gamma-chain (gamma(c))." The "ligand-binding properties of IL ... and IL-4 bind to partially overlapping epitopes of common gamma-chain. Biochem Biophys Res Commun, 2003;300(2):291-296 ...

Article: Diagnostic validation of capillary electrophoresis analysis of ...
Clinical Chemistry;  March 1, 2003 ;     700+ words ... ... evolving lymphoma development (3). We present here our validation data of the use of CE in the analysis of T-cell receptor [gamma]-chain (TCR[gamma]) gene rearrangements for clinical use. We also present a report of a case that was judged to be benign based ...