Article: Clinic Roundup.

o CuraGen Corp., of Branford, Conn., and TopoTarget A/S, of Copenhagen, Denmark, started a Phase I trial evaluating the administration of oral PXD101, a small-molecule histone deacetylase inhibitor, in patients with advanced solid tumors. The open-label, multicenter trial is designed to establish the maximum tolerated dose for oral PXD101 administered once or twice daily. Patients in the U.S. and Europe will be treated with oral PXD101 in a dose-escalation regimen and may continue to receive up to eight or more treatment cycles depending on disease response. Preliminary results are expected by the end of 2007.

o MGI Pharma Inc., of Minneapolis, said the FDA has ...

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