Article: Adolor, With Partner GSK, Initiate Entereg Phase III.

Washington Editor

Partners Adolor Corp. and GlaxoSmithKline plc began a broad Phase III program to investigate the use of Entereg (alvimopan) for opioid-induced constipation and associated symptoms.

"The results from Phase IIb studies were very positive and very encouraging," said James Barrett, a senior vice president at Adolor and its chief scientific officer. "I think the shear, overwhelming positive nature of those studies provided a lot of impetus to really get [Phase III] going very quickly."

The international program is made of three studies expected to enroll about 1,700 patients in North America, Europe and other parts of the world. ...

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