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o AEterna Zentaris Inc., of Quebec City, reported in vitro data on the anti-angiogenic properties of perifosine at the Strategic Research Institute's conference on angiogenesis in Cambridge, Mass. The new findings demonstrate that the first-in-class, oral signal transduction/AKT inhibitor supresses the formation of new endothelial capillaries, characteristic of angiogenesis. Previously reported in vitro data had demonstrated perifosine's ability to modulate multiple signal transduction pathways involved in growth/proliferation and survival of cancer cells, induce apoptosis, act as a radiosensitizer and to enhance radiation-induced apoptosis.

o Biolex Inc., of ...

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