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o Alkermes Inc., of Cambridge, Mass., said results of a Phase III extension study of Vivitrex (naltrexone long-acting injection) in alcohol-dependent patients show that the drug plus counseling led to a sustained reduction in heavy drinking over an 18-month period. The trial included 332 patients - about 85 percent of the subjects enrolled in the initial six-month study - who received Vivitrex in 380-mg or 190-mg doses. Those who continued on active treatment with 380 mg demonstrated a sustained reduction in levels of heavy drinking. The median number of heavy drinking days on Vivitrex treatment in the main trial was similar to the number during the 12-month extension ...

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