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o Amylin Pharmaceuticals Inc., of San Diego, said a dose-titration study of its diabetes drug candidate Symlin (pramlintide acetate) met prospectively defined parameters for its non-inferiority objective. In addition to reductions in HbA1c consistent with the non-inferiority objective in the 296-patient study, Symlin-treated subjects used 12 percent less insulin overall compared to control. Symlin also was associated with a significant reduction in post-meal blood glucose concentrations compared to the group using insulin alone, and the effect was sustained over the entire seven months of the study. At the end, Symlin-treated subjects experienced a reduction in weight, ...

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