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AVI BioPharma Inc., of Portland, Ore., reported in this month's issue of Clinical Cancer Research results of a Phase II trial testing its Avicine cancer vaccine in patients with late-stage colorectal cancer. In the randomized, multicenter, 77-patient study, anti-hCG antibodies were detected in 56 patients. An intention-to-treat analysis of all vaccinated patients showed a median survival of 34 weeks. Patients who developed higher anti-hCG antibody levels exhibited a median survival of 45 weeks. Subsequent analysis showed that patients who produced the antibodies to two segments of the hCG peptide had a median survival of 66 weeks.

Axonyx Inc., of New York, ...

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