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Article: New pediatric cardiology data have been reported by scientists at Shanghai Jiao Tong University, Medical Department.
- Article from:
- Pediatrics Week
- Article date:
- November 14, 2009
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According to recent research published in the journal Pediatric Cardiology, "Closure of the ductus arteriosus (DA) after birth, essential for postnatal adaptation, is initiated by the transition from hypoxia to normoxia. The current study investigated how hypoxia affects the level of cytosolic calcium ([Ca2+](i)) in fetal lamb DA smooth muscle cells (DASMCs) and the role of calcium pumps in this process."
"The [Ca2+](i) variation in response to acute hypoxia was determined spectrofluorometrically with fura-3-AM in cultured fetal DASMCs. using chemicals or solutions including thapsigargin, vanadate, KB-R7943, alkaline PH9.0 solution, or Na+-free medium were ...