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Article: Investigators at Manchester Metropolitan University release new data on angiogenesis.
- Article from:
- Angiogenesis Weekly
- Article date:
- November 13, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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"We used short-interfering RNA (siRNA) to knockdown the hyaluronan (HA) receptors CD44 and the receptor for hyaluronan-mediated motility (RHAMM) in vascular endothelial cells to investigate their role in angiogenesis. We showed that CD44 and RHAMM single knock-down inhibited low molecular weight hyaluronan (o-HA)-induced endothelial cell tube formation in Matrigel, but no change in the control, epidermal growth factor-induced tube formation was observed," investigators in Manchester, the United Kingdom report (see also Angiogenesis).
"Using a Kinexus phosphoprotein array and confirmational Western blotting we were able to show a differential effect on HA-induced ...
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