Article: Research from Japan Tobacco, Inc. in the area of obesity and diabetes published.

"Spontaneously Diabetic Torii (SDT) rat shows severe ocular complications such as tractional retinal detachment. In the present study, effect of protein kinase C beta (PKC beta) inhibitor JTT-010 was evaluated to clarify the involvement of PKC beta in complications of SDT rat," scientists writing in the journal Diabetes Obesity & Metabolism report (see also Obesity and Diabetes).

"SDT rats were administered JTT-010 (10 or 50 mg/kg/day) for 48 weeks. SDT rats showed delayed oscillatory potentials in electroretinogram. Delayed motor nerve conduction velocity, decreased coefficients of variation of R-R intervals in electrocardiogram and thermal hypoalgesia were also ...

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