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Article: Studies from University of Texas describe new findings in vascular endothelial growth factor.
- Article from:
- Angiogenesis Weekly
- Article date:
- November 13, 2009
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"Epidermal cell migration is critical for restoration of tissue structure and function after damage [1]. However, the mechanisms by which differentiated cells neighboring the wound sense the wound and assume a motile phenotype remain unclear," scientists writing in the journal Current Biology report (see also Vascular Endothelial Growth Factor).
"Here, we show that Pvr, a receptor tyrosine kinase (RTK) related to platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) receptors, and one of its ligands, Pvf1, are required for epidermal wound closure. Morphological comparison of wound-edge cells lacking Pvr or the Jun N-terminal kinase ...