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Article: Investigators at University of Missouri, Medical Department target enzyme research.
- Article from:
- Biotech Week
- Article date:
- November 11, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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"E3 ubiquitin ligases, which target specific molecules for proteolytic destruction, have emerged as key regulators of immune functions. Several E3 ubiquitin ligases, including c-Cbl, Cbl-b, GRAIL, Itch, and Nedd4, have been shown to negatively regulate T-cell activation," scientists writing in the journal Molecular and Cellular Biology report (see also Enzyme Research).
"Here, we report that the HECT-type E3 ligase AIP2 positively regulates T-cell activation. Ectopic expression of AIP2 in mouse primary T cells enhances their proliferation and interleukin-2 production by suppressing the apoptosis of T cells. AIP2 interacts with and promotes ubiquitin-mediated ...
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Article: Research from Tohoku University, Medical Department ...
Science Letter;
October 28, 2008 ;
700+ words
... ... University, Medical Department (see also Molecular and Cellular Biology). The researchers ... Molecular and Cellular Biology can be contacted ... Molecular and Cellular Biology, Tohoku University, Medical Department. This article ...
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