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Article: New findings in enzyme research described from Duke University.
- Article from:
- Biotech Week
- Article date:
- November 11, 2009
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According to a study from the United States, "Reactive oxygen species are ubiquitous mutagens that have been linked to both disease and aging. The most studied oxidative lesion is 7,8-dihydro-8-oxoguanine (GO), which is often miscoded during DNA replication, resulting specifically in GC → TA transversions."
"In yeast, the mismatch repair (MMR) system repairs GO (.) A mismatches generated during DNA replication, and the polymerase eta (Pol eta) translesion synthesis DNA polymerase additionally promotes error-free bypass of GO lesions. It has been suggested that Pol eta limits GO-associated mutagenesis exclusively through its participation in the filling of ...
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