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Article: Scientists at University of Strathclyde describe research in enzyme research.
- Article from:
- Biotech Week
- Article date:
- November 11, 2009
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According to a study from Scotland, "Store-operated Ca2+ entry(SOCE) is an important mechanism for Ca2+ influx in smooth muscle cells; however the activation and regulation of this influx pathway are incompletely understood. In the present study we have examined the effect of several protein kinases in regulating SOCE in pulmonary artery smooth muscle cells (PASMCs) of the rat."
"Inhibition of protein kinase C with chelerythrine (3 mc M) potentiated SOCE by 47 +/- 2%, while the tyrosine kinase inhibitors genistein (100 mc M) and tyrphostin 23 (100 mc M) caused a significant reduction in SOCE of 55 +/- 9% and 43 +/- 7%, respectively. It has been proposed that ...