Article: Data on gastroenterology published by researchers at University of Texas.(Report)

According to a study from the United States, "FoxO4 is a member of the forkhead box transcription factor O (FoxO) subfamily. FoxO, proteins are involved in diverse biological processes."

"In this study, we examine the role of FoxO4 in intestinal mucosal immunity and inflammatory bowel disease (IBD). Foxo4-null mice were subjected to trinitrobenzene sulfonic acid (TNBS) treatment. Microarray analysis and quantitative reverse transcription polymerase chain reaction were used to identify the cytokine transcripts that were altered by Foxo4 deletion. The effects of Foxo4 deficiency on the intestinal epithelial permeability and levels of tight junction proteins were ...

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