Article: Scientists at Xiamen University describe research in hepatomas.

According to recent research from Xiamen, People's Republic of China, "In evaluating the cytotoxic effects and the mechanisms of the apoptotic and necrotic actions of trimethyltin chloride (TMT) on human hepatoma G2 (HepG2) cells, the present Study focused on the involvement of antiproliferation, DNA damage, cell death, apoptosis-related proteins, and p53-dependent transcriptional activity. Twenty-four hour TMT treatments (4-64, mc M) induced apoptosis and necrosis in HepG2 cells."

"Thirty-two micromolar and higher concentration significantly increases cell death. DNA damage was observed at 8 mc M. Additionally, TMT increased the activity Of cellular caspase-3 ...

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