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Article: Research from F.Y. Wang and co-researchers in the area of life sciences published.
- Article from:
- Biotech Week
- Article date:
- November 11, 2009
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According to recent research published in the Journal of Biological Inorganic Chemistry, "The organoruthenium complex [(eta(6)-hmb)Ru(en)(Cl)][PF6] (hmb is hexamethylbenzene, en is ethylenediamine) undergoes facile aquation and then reacts with KSCN in unbuffered solution to give the S-coordinated thiocyanato product [(eta(6)-hmb)Ru(en)(S-SCN)](+) which slowly converts to the thermodynamically favored N-bound complex [(eta(6)-hmb)Ru(en)(N-NCS)](+) (1 (+)). Complex 1 was synthesized and characterized by X-ray crystallography and mass spectrometry."
"Despite its lack of hydrolysis over 24 h, complex 1 exhibits moderate cytotoxicity (IC50 24 mc M) towards the human ...