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Article: Researchers at City University of New York publish new data on life sciences.
- Article from:
- Biotech Week
- Article date:
- November 11, 2009
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"The convergent synthesis of two pentacyclic analogues of the polyether monensin A is described," scientists in the United States report (see also Life Sciences).
"Although different with respect to the configuration of the alcohol at the 3 position of the six-membered ring of the spiroketal subunit, the configuration at the acetal center in both structures is unchanged and is consistent with the anomeric effect. The key synthetic steps are the coupling of two complex segments via an olefin metathesis, and the subsequent conversion of a dihydroxyalkene to the spiroketal through an iodoetherification-dehydroiodination sequence," wrote K.A. Tony and colleagues, ...