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Article: Technical University of Munich reports research in life sciences.
- Article from:
- Biotech Week
- Article date:
- November 11, 2009
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According to recent research published in the journal Acta Crystallographica Section D - Biological Crystallography, "Tear lipocalin (TLC) with the bound artificial ligand 1,4-butanediol has been crystallized in space group P2(1) with four protein molecules in the asymmetric unit and its X-ray structure has been solved at 2.6 angstrom resolution. TLC is a member of the lipocalin family that binds ligands with diverse chemical structures, such as fatty acids, phospholipids and cholesterol as well as microbial siderophores and the antibiotic rifampin."
"Previous X-ray structural analysis of apo TLC crystallized in space group C2 revealed a rather large bifurcated ...