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Article: Research from T. Yoshizawa and co-authors reveals new findings on metabolism.
- Article from:
- Biotech Week
- Article date:
- November 11, 2009
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According to a study from the United States, "The recent demonstration that osteoblasts have a role in controlling energy metabolism suggests that they express cell-specific regulatory genes involved in this process. Activating transcription factor 4 (ATF4) is a transcription factor that accumulates predominantly in osteoblasts, where it regulates virtually all functions linked to the maintenance of bone mass."
"Since Atf4(-/-) mice have smaller fat pads than littermate controls, we investigated whether ATF4 also influences energy metabolism. Here, we have shown, through analysis of Atf4(-/-) mice, that ATF4 inhibits insulin secretion and decreases insulin ...