Article: Research on periodontitis detailed by V.M. Barnes and co-authors.(Report)

"Periodontal diseases, such as gingivitis and periodontitis, are characterized by bacterial plaque accumulation around the gingival crevice and the subsequent inflammation and destruction of host tissues. To test the hypothesis that cellular metabolism is altered as a result of host-bacteria interaction, we performed an unbiased metabolomic profiling of gingival crevicular fluid (GCF) collected from healthy, gingivitis, and periodontitis sites in humans, by liquid and gas chromatography mass spectrometry," investigators in the United States report (see also Periodontitis).

"The purine degradation pathway, a major biochemical source for reactive oxygen species ...

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