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Article: Studies in the area of schizophrenia reported from University of Bradford.(Report)
- Article from:
- Biotech Week
- Article date:
- November 11, 2009
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"5-HT receptor mechanisms have been suggested to mediate improvements in cognition in schizophrenia. The aim of this study was to investigate the involvement of 5-HT receptor mechanisms in sub-chronic phencyclidine (PCP)-induced reversal learning deficits in female rats, a task of relevance to schizophrenia," researchers in Bradford, the United Kingdom report (see also Schizophrenia).
"Adult female hooded Lister rats were trained to perform an operant reversal learning task and then received sub-chronic PCP (2 mg/kg) or vehicle intraperitoneally (i.p.) twice daily for 7 days, followed by 7-day washout. Rats then received an acute dose of the 5-HT7 receptor ...