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Article: University of Kentucky describes research in amyotrophic lateral sclerosis genetics.
- Article from:
- Biotech Week
- Article date:
- November 11, 2009
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A report, 'Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism,' is newly published data in Journal of Neurochemistry. According to recent research from the United States, "The p62/sequestosome 1 protein has been identified as a component of pathological protein inclusions in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). P62 has also been implicated in autophagy, a process of mass degradation of intracellular proteins and organelles."
"Autophagy is a critical pathway for degrading misfolded and/or damaged proteins, including the copper-zinc superoxide dismutase (SOD1) mutants linked to ...