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Article: Data on enzyme research discussed by researchers at Northwestern University.
- Article from:
- Gene Therapy Weekly
- Article date:
- November 12, 2009
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"The precise STAT-regulated gene targets that inhibit cell growth and generate the antitumor effects of Type I interferons (IFNs) remain unknown. We provide evidence that Type I IFNs regulate expression of Schlafens (SLFNs), a group of genes involved in the control of cell cycle progression and growth inhibitory responses," scientists writing in the Journal of Biological Chemistry report (see also Enzyme Research).
"Using cells with targeted disruption of different STAT proteins and/or the p38 MAP kinase, we demonstrate that the IFN-dependent expression of distinct Schlafen genes is differentially regulated by STAT complexes and the p38 MAP kinase pathway. We ...
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