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Article: Research from X.D. Li and co-researchers in the area of bone research published.
- Article from:
- Blood Weekly
- Article date:
- November 12, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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"Orchiectomized (ORX) rats were used to examine the extent to which their increased bone resorption and decreased bone density might relate to increases in RANKL, an essential cytokine for bone resorption. Serum testosterone declined by >95% in ORX rats 1 and 2 weeks after Surgery (p
"In contrast, RANKL in bone marrow plasma and bone marrow cell extracts was significantly increased (by similar to 100%) 1 and 2 weeks after ORX. Regression analyses of OPX and sham controls revealed a significant inverse Correlation between testosterone and RANKL levels measured in marrow cell extracts (R = -0.58), while marrow plasma RANKL correlated positively with marrow plasma TRACP-5b, ...
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