Article: Reports from William Beaumont Hospital advance knowledge in enzyme research.(Clinical report)

"Acute hepatic failure is traditionally diagnosed on the basis of clinical presentation, historical information, and a collection of abnormal laboratory findings including elevated aspartate aminotransferase, alanine aminotransferase, prothrombin time, serum bilirubin and alpha-fetoprotein. Non-specific haematological findings such as anaemia, thrombocytopenia and changes in erythrocyte morphology are well documented in patients with liver failure," investigators in the United States report (see also Enzyme Research).

"It is believed, however, that there are no specific morphological findings on peripheral blood smears directly linked to liver failure. This ...

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