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Article: Studies conducted at Duke University on leukemia recently published.
- Article from:
- Blood Weekly
- Article date:
- November 12, 2009
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According to a study from the United States, "We compared the expression of CD123, the a chain of the interleukin-3 receptor, on normal B-cell precursors in bone marrow (''hematogones'') from 75 specimens and on leukemic blasts in 45 newly diagnosed B-acute lymphoblastic leukemias (B-ALL) cases."
"We found that the less mature hematogones (dim CD45+) that express CD34 lack CD123 expression, whereas the more mature hematogones (moderate CD45+) lack CD34 but always express CD123. In contrast with this discordant pattern of CD34 and CD123 expression in hematogones, blasts in 41 (91%) of 45 cases of B-ALL showed concordant expression of the 2 antigens: 80% (36 of ...