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Article: Studies conducted at University of British Columbia on cancer recently published.
- Article from:
- Cancer Weekly
- Article date:
- November 10, 2009
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According to recent research published in the journal Planta Medica, "One of the major causes for cancer cells to resist current chemotherapy is attributed to the overexpression of P-glycoprotein (P-gp), resulting in insufficient drug delivery to the tumor sites. Protopanaxadiol ginsenosides Rg3 and Rh2 are known to induce apoptosis and significantly enhance the tumor inhibitory effects of chemotherapeutics in a synergistic fashion."
"One of the possible mechanisms is by blocking P-gp activity. The final deglycosylation metabolite of protopanaxadiols (PPDs) in vivo is 20(S)-protopapanaxadiol (aglycone PPD, aPPD), which has also shown anticancer activity and ...