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Article: Researchers from National Institutes of Health provide details of new studies and findings in the area of physiology.
- Article from:
- Health & Medicine Week
- Article date:
- November 9, 2009
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"Synaptic development is an activity-dependent process utilizing coordinated network activity to drive synaptogenesis and subsequent refinement of immature connections. Hippocampal CA3 pyramidal neurons (PYRs) exhibit intense burst firing (BF) early in development, concomitant with the period of mossy fibre (MF) development," scientists in the United States report (see also Physiology).
"However, whether developing MF-PYR synapses utilize PYR BF to promote MF synapse maturation remains unknown. Recently, we demonstrated that transient tonic depolarization of postsynaptic PYRs induces a persistent postsynaptic form of long-term depression (depolarization-induced ...