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Article: Researchers from University of California publish new studies and findings in the area of cardiomyopathy.
- Article from:
- Heart Disease Weekly
- Article date:
- November 15, 2009
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"Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in cardiac contractility and heart disease. However, the specific role of alternatively spliced variants of CaMKII in cardiac disease and apoptosis remains poorly explored," scientists writing in the Journal of Biological Chemistry report (see also Cardiomyopathy).
"Here we report that the delta B subunit of CaMKII (CaMKII delta B), which is the predominant nuclear isoform of calcium/calmodulin- dependent protein kinases in heart muscle, acts as an anti-apoptotic factor and is a novel target of the antineoplastic and cardiomyopathic drug doxorubicin (Dox(adriamycin)). Hearts of rats that ...