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Article: Research in the area of heart failure reported from University of Queensland.(Report)
- Article from:
- Heart Disease Weekly
- Article date:
- November 15, 2009
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According to a study from Brisbane, Australia, "3-hydroxy-3-methylglutaryl(HMG)-Coenzyme(Co)A reductase inhibitors such as rosuvastatin may improve clinical status in patients with hypertension and heart failure. The aging spontaneously hypertensive rat (SHR) closely mimics the chronic heart failure disease process observed in humans."
"This study examined the structural and functional changes in the cardiovascular system of 15-month-old SHR and normotensive Wistar-Kyoto (WKY) rats treated with rosuvastatin (20 mg/kg/day perorally) for 24 weeks. Cardiovascular structure and function were monitored serially by echocardiography. At 21 months, ex vivo Langendorff, ...