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Article: New dengue fever study findings reported from University of London, Imperial College.
- Article from:
- Medical Letter on the CDC & FDA
- Article date:
- November 15, 2009
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"Dengue viruses belong to the Flavivirus family and are responsible for hemorrhagic fever in Human. Dengue virus infection triggers apoptosis especially through the expression of the small membrane (M) protein," scientists in London, the United Kingdom report (see also Dengue Fever).
"Using isolated mitochondria, we found that synthetic peptides containing the C-terminus part of the M ectodomain caused apoptosis-related mitochondrial membrane permeabilization (MMP) events. These events include matrix swelling and the dissipation of the mitochondrial transmembrane potential (Delta I-m). Protein M Flavivirus sequence alignments and helical wheel projections reveal ...