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Article: Study findings from University of South Carolina provide new insights into obesity and diabetes.
- Article from:
- Obesity & Diabetes Week
- Article date:
- November 9, 2009
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"S-(2-Succinyl) cysteine (2SC) is formed by reaction of the Krebs cycle intermediate fumarate with cysteine residues in protein, a process termed succination of protein. Both fumarate and succination of proteins are increased in adipocytes cultured in high glucose medium (Nagai, R., Brock, J. W., Blatnik, M., Baatz, J. E., Bethard, J., Walla, M. D., Thorpe, S. R., Baynes, J. W., and Frizzell, N. (2007) J. Biol. Chem. 282, 34219-34228)," scientists writing in the Journal of Biological Chemistry report (see also Obesity and Diabetes).
"We show here that succination of protein is also increased in epididymal, mesenteric, and subcutaneous adipose tissue of diabetic ...
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