Article: Study findings from Semmelweis University provide new insights into enzyme research.

"Angiotensin II elicits cytosolic Ca2+ signal that is transferred into the mitochondria. Previously we found in H295R cells that this signal transfer is enhanced by both the inhibition of p38 MAPK and a novel isoform of PKC [G. Szanda, P. Koncz, A. Rajki, A. Spat, Participation of p38 MAPK and a novel-type protein kinase C in the control of mitochondrial Ca2+ uptake, Cell Calcium 43 (2008) 250-259]," investigators in Budapest, Hungary report (see also Enzyme Research).

"Now we report that simultaneous activation of these protein kinases (by TNF alpha and PMA + an inhibitor of the conventional PKC isoforms, respectively) attenuates the transfer of cytosolic Ca2+ ...

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